Proverbs 18:14 English Standard Version (ESV) A man’s spirit will endure sickness, but a crushed spirit who can bear?
Sin is the sickness of the spiritually dead. Sin for a time is fun, physically pleasing but over time it will crush the life out of you. The spirit spoken of here is the life force of mankind, not the Holy Spirit. The only cure for the sin of death is life in Christ. It is then that the Holy Spirit is given and takes over the spirit of life in mankind.
Every sin has its own manifestation of its disease. Greed will manifest itself differently than lust. What will be common among all the manifestations of sin is the wearing down of ones soul with the weight of its insistence. It will become unfulfilling, leaving us with a sense of emptiness.
Things will not buy happiness, no matter how much money you throw at it. Lust is not love and will never satisfy the longing to be loved. These are the easiest sins to example but if one is caught up in one of the others, sin we present itself as insufficient to satisfy what is truly missing.
We miss God if we have never heard of Him. Mankind who have never heard of the one true God has invented idols and vanities to fill that emptiness without properly understanding.
Man has worshipped false gods for a long time. Gods of volcanos, gods of fire, gods of water, gods of the air, god spirits of animals and the vanities of vanities in declaring men to be gods. That is part of mankind’s history. We can make wisdom and knowledge a god if we find that satisfying to the mind, but they cannot satisfy what God has placed in us all.
God placed in us a longing for a relationship with our creator.